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Read articles ↓The landmark Meier PNAS 2012 study followed users from age 13 to 38 and found persistent cannabis users lost an average of 8 IQ points.
Read article →About 1 in 3 daily users develop cannabis use disorder. Withdrawal is real — irritability, insomnia, anxiety — and peaks in the first week.
Read article →Driving after cannabis use roughly doubles the risk of a serious motor-vehicle crash, per a BMJ meta-analysis and subsequent NHTSA research.
Read article →A 2024 European Archives of Psychiatry review synthesizes the strongest evidence on cannabis-related health risks across psychiatric and physical outcomes.
Read article →A 2024 Journal of the American Heart Association study linked cannabis use to elevated risk of heart attack and stroke, even in younger adults.
Read article →Across the literature, cannabis use is associated with elevated risk of anxiety, depression, and psychosis — with heavy and adolescent users at highest risk.
Read article →A 2025 JAMA study links cannabis legalization to measurable increases in schizophrenia and psychosis diagnoses, particularly in young heavy users.
Read article →A 2023 BMJ umbrella review of 101 meta-analyses found cannabis-related harms are well-supported while many claimed benefits lack strong evidence.
Read article →A 2024 Annual Review of Medicine paper catalogues the adverse health effects of marijuana across cardiovascular, respiratory, cognitive, and psychiatric domains.
Read article →A 2025 JAMA Cardiology study found both smoked cannabis and edibles are associated with reduced vascular function, even in healthy adults.
Read article →A 2025 JAMA review of medical cannabis evidence through September 2025 concludes that most claimed therapeutic benefits lack adequate clinical support.
Read article →A 2023 Clinical Epigenetics study found THC use during pregnancy alters DNA methylation patterns in the developing fetus, with potential long-term effects.
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